Russian S-300 air defense missile systems during a military parade in the Red Square in Moscow, Russia (AP)

The Israeli occupation on Tuesday said its fighter jets were attacked by Russian anti-aircraft systems during a flight over Syria in May in what "Tel Aviv" said was a "one-off incident".

The Israeli occupation made the revelation amid tensions with Russia over "Tel Aviv's" support for Kiev in the midst of the Ukraine war and Moscow's dissolution of the Jewish Agency for Israel on its territories.

Top Russian officials clarified that the investigation was not a political move against the occupation. However, Israeli officials fear that it might be a sign of Moscow's dissatisfaction with "Tel Aviv's" foreign policy toward Ukraine, Israeli media said.

Israeli Channel 13 reported that a Russian-operated S-300 air defense battery opened fire on May 13 against Israeli jets as they were waging aggression on Syria. However, no aggressive jets were hit during the attack.

"It was a one-off incident," Israeli occupation Security Minister Benny Gantz told a conference hosted by Channel 13 when asked to confirm the report. The Russian launch happened when the aircraft "were no longer around", he said.

For the first time since the Israeli occupation started conducting offensives in Syria, an S-300 air defense system launched a SAM toward an aircraft of the Israeli occupation air force during the latest aggression on Masyaf, Syria, Israeli media reported on May 16.

"For the first time since the beginning of the attacks on Syria, a Russian air defense system fired an S-300 missile toward an [Israeli] air force aircraft," Israeli Channel 13 military affairs commentator Alon Ben David said.

The Russian ministry of defense had revealed two days earlier that Israeli F-16s fired 22 missiles toward a Syrian scientific research center in Masyaf and the Baniyas port, which were intercepted. The air defense systems downed 16 missiles out of the 22.

Russian Reconciliation Center for Syria deputy chief Oleg Zhuravlyov announced that six Israeli F-16s attacked on May 13 between 20:25 and 20:32 sites for the Syrian scientific research center in Masyaf and Baniyas without entering Syrian airspace.

The Israeli aggression, the Russian official said, killed three Syrian soldiers and two civilians, with two Syrian soldiers sustaining injuries. The attack also caused material damage to equipment in the research center.