Undated photo of a Russian S-300 anti-aircraft missile system on display in an undisclosed location in Russia

For the first time since the Israeli occupation started conducting offensives in Syria, an S-300 air defense system launched a SAM toward an aircraft of the Israeli occupation air force during the latest aggression on Masyaf, Syria, Israeli media reported on Monday.

"For the first time since the beginning of the attacks on Syria, a Russian air defense system fired an S-300 missile toward an [Israeli] air force aircraft," Israeli Channel 13 military affairs commentator Alon Ben David said.

The Russian ministry of defense had revealed Saturday that Israeli F-16s fired 22 missiles toward a Syrian scientific research center in Masyaf and the Baniyas port, which were intercepted. The air defense systems downed 16 missiles out of the 22.

Russian Reconciliation Center for Syria deputy chief Oleg Zhuravlyov announced that six Israeli F-16s attacked on May 13 between 20:25 and 20:32 sites for the Syrian scientific research center in Masyaf and Baniyas without entering Syrian airspace.

"The Air Defense Forces in the Syrian Arab Republic were able to down 16 missiles and a UAV Israel used in the attack," Zhuravlyov added.

The Israeli aggression, the Russian official said, killed three Syrian soldiers and two civilians, with two Syrian soldiers sustaining injuries. The attack also caused material damage to equipment in the research center.